Process Controllers and Analyzers
Medchemexpress LLC ZD-4190 100mg | 100mg
ZD-4190 is a potent orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling used for the treatment of cancer
Apexbio Technology LLC ZD 7288(Synonyms: ZD7288, Zatebradine hydrochloride, HCN channel inhibitor ZD7288), 50mg, CAS: 133059-99-1.
ZD 7288 (CAS 133059-99-1) is a selective inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels These channels mediate Na and K currents notably the hyperpolarization-activated current (I h) contributing to neuronal excitability and rhythmic activity ZD 7288 reduces I h in a concentration-dependent voltage- and time-sensitive manner as demonstrated in rat facial motoneurons (IC 50 0 2 M) and hippocampal CA1 pyramidal neurons Additionally it inhibits T-type calcium currents in rat CA1 pyramidal cells ZD 7288 is utilized in research investigating neuronal excitability mechanisms pain signaling and chronic visceral pain models
Cayman Chemical ZD 7155hydrochlorIde 10mg
An AT1 receptor antagonist (IC50 = 3.3 nM); inhibits angiotensin II-induced pressor responses in conscious normotensive rats; decreases mean arterial pressure in conscious spontaneously hypertensive rats at 1.082 µmol/kg; improves motor nerve conduction velocity in the sciatic nerve in a rat model of streptozotocin-induced diabetic neuropathy at 10 mg/kg in the drinking water; decreases disease severity and NF-κB and AP-1 activation in a mouse model of LPS-induced acute lung injury at 10 mg/kg
Apexbio Technology LLC ZD 7288(Synonyms: ZD7288, Zatebradine hydrochloride, HCN channel inhibitor ZD7288), 5mg, CAS: 133059-99-1.
ZD 7288 (CAS 133059-99-1) is a selective inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels These channels mediate Na and K currents notably the hyperpolarization-activated current (I h) contributing to neuronal excitability and rhythmic activity ZD 7288 reduces I h in a concentration-dependent voltage- and time-sensitive manner as demonstrated in rat facial motoneurons (IC 50 0 2 M) and hippocampal CA1 pyramidal neurons Additionally it inhibits T-type calcium currents in rat CA1 pyramidal cells ZD 7288 is utilized in research investigating neuronal excitability mechanisms pain signaling and chronic visceral pain models
Medchemexpress LLC N-(4-methoxybenzoyl)-L-valyl-N-(trifluoro-oxopentan-3-yl)pyrrolidine-2-carboxamide | 171964-73-1 | 95.0% | 499.5 g/mol | C24H32F3N3O5 | 10 MG
ZD-0892 is a small-molecule, selective inhibitor of neutrophil elastase with reported Ki values of 6.7 nM for human neutrophil elastase and 200 nM for porcine pancreatic elastase. It is supplied as a research-grade reagent (purity 95%) and is used in biochemical and enzymatic studies to probe elastase-dependent pathways.
- Selective inhibition of human neutrophil elastase (Ki ~6.7 nM).
- Also inhibits porcine pancreatic elastase (Ki ~200 nM).
- Suitable for biochemical and enzymatic assays.
- Provided at research-grade purity for reproducible results.
- Small-molecule compound with molecular weight approximately 499.5 g/mol.
Apexbio Technology LLC ZD 9379 10mg
ZD 9379 (CAS 170142-20-8) is a small molecule that acts as an antagonist at the glycine-binding site of the NMDA receptor Exhibiting oral bioavailability and capable of crossing the blood-brain barrier ZD 9379 modulates neuronal signaling by inhibiting NMDA receptor-mediated pathways Experimental studies have demonstrated its capacity to suppress functions associated with the central nervous system Due to its pharmacological profile ZD 9379 is primarily employed in the investigation of neurological disease models and the elucidation of NMDA receptor-related mechanisms
Cayman Chemical ANTIBODY ZD 7288 50mg
A potent blocker of HCN channels that inhibits HCN4 more potently than HCN1 (IC50s = 32 and 158 nM, respectively); modulates the sinoatrial node and slows heart rate; reduces neuropathic pain in several animal models
Cayman Chemical ANTIBODY ZD 7288 25mg
A potent blocker of HCN channels that inhibits HCN4 more potently than HCN1 (IC50s = 32 and 158 nM, respectively); modulates the sinoatrial node and slows heart rate; reduces neuropathic pain in several animal models